PAGNI, Haematology Department, Heraklion Crete, PO 1352 +30 2810-392-344 +30 2810-392-426

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HELEN-2Helen A. Papadaki, MD, PhD
Professor of Haematology,


University of Crete School of Medicine
Head of the Department of Haematology,
University Hospital of Heraklion
PO Box 1352 , Heraklion, Crete, Greece
Tel: +30 2810 392805
Fax: +30 2810 394632
E-mail: epapadak [at] med.uoc.gr
http://haematology.med.uoc.gr


 

 

CURRENT POSITION

Professor of Haematology, University of Crete, School of Medicine.

Head, Department of Haematology, Autologous Haemopoietic Stem Cell Transplantation Unit and Public Umbilical Cord Blood Bank of Crete, University Hospital of Heraklion, Crete, Greece.

Head, Haemopoiesis Research Laboratory, University of Crete, School of Medicine.

Head, Flow Cytometry Laboratory, University of Crete, School of Medicine.

 

EDUCATION-TRAINING
1981-1987:          MD, Medical School, University of Athens (with honors)
1991-1995: PhD (Heamatology-Immunology), University of Crete, School of Medicine (with honors)
1989-1996:  Specialization in Haematology, Department of Haematology, University Hospital of Heraklion, Crete, Greece
1999-2000: Research Fellow (EMBO Fellowship), Saint George’s Medical School, London, UK
2002: Visiting Professor (sabbatical), Institute for Cancer Studies, Birmingham, UK
2007: Visiting Professor (sabbatical), Department of Haematology, University of Washington, Seattle, USA.

                         

POSITIONS AND HONORS
2016-20:  Elected Councilor on the European Haematology Association Board
2016-18: Appointed member of the expert committee for the approval of the biologic and blood-derived cellular products and the Advanced Therapy Medicinal Products (ATMP) of the National Organization for Medicines.  
2013-15: 
 Deputy Rector for Academic Affairs, University of Crete, Greece.
2014-today:  Deputy Director of the Graduate Program “Molecular Basis of Human Diseases”, School of Medicine, University of Crete (2006-2014 member of the Steering Committee).
2012: Member of the Expert Committee for the therapeutic guidelines for Haematologic Disorders, National Organization of Medicines, Greece.
2011-15: Director of the Pre-Graduate Study Committee, School of Medicine, University of Crete (2003-2011 member of the Committee).
2011-today:   Member of the Steering Committee of the Scientific Working Group of Granulocyte and Monocyte Disorders of the European Haematology Association
2009-2013: Head of the Scientific Working Group on Bone Marrow Failure and Myelodysplastic Syndromes of the Hellenic Haematology Association (2007-2009 vice president, 2005-2007 head).
2007-today: Professor of Haematology, Head of the Department of Haematology of the University Hospital of Heraklion, Head of the Haemopoiesis Research Laboratory of the University of Crete School of Medicine
2007-today: President of the examination committee for the Specialization of Haematology in Crete.
2007-10: Head of the Scientific Working Group on Granulocyte and Monocyte Disorders of the European Haematology Association
2003-today: Head of the Flow Cytometry Lab of the University of Crete, School of Medicine
2002-2007: Assistant Professor of Haematology, University of Crete School of Medicine.
2002-today: Local liaison physician for the Severe Chronic Neutropenia International Registry.
1997-2002: Lecturer of Haematology, University of Crete School of Medicine.

 

REVIEWER IN JOURNALS

Blood, Haematologica/The Hematology Journal, British Journal of Hematology, Leukemia, Experimental Hematology, Stem Cells and Development, Tissues Engineering, Leukemia Research, Cancer Letter, Arthritis and Rheumatism, Annals of Rheumatic Diseases, Journal of Autoimmunity, Journal of Cellular Biochemistry, Leukemia & Lymphoma, Cell Proliferation, Journal of Rheumatology, Trends in Molecular Medicine, Journal of Infectious Diseases, Expert Opinion on Biological Therapy, Journal of Internal Medicine, Acta Hematologica.

 
EXPERT REVIEWER

European Research Council, E.U.; E-rare, European Research Projects on Rare Diseases, E.U.; The Arthritis Research Campain Organization (UK); Cancer Research UK Grants; Sultan Qaboos University; Health Research Board (HRB)– Patient Oriented Research Committee, Dublin, Ireland; Norwegian Stem Cell Center, Research Council of Norway.

 

INVITED SPEAKER - ORGANIZATION OF INTERNATIONAL CONFERENCES

Invited speaker in more than 100 national and international conferences.

Organization of two International Neutropenia Network Conferences (2001, 2005); PNH International Meeting (2011) with an unrestricted educational grant from Alexion; Advanced Training Course on Chronic Lymphocytic Leukemia addressed to trainees in Haematology and young haematologists from different parts of South-East Europe (Bulgaria, Slovakia, Estonia, Romania, Latvia, Switzerland, Austria, Hungary, Serbia and Greece) (2012), in the University of Crete, School of Medicine.

 

REPRESENTATIVE RESEARCH GRANTS

Association for International Cancer Research, AICR. “Study of the in vivo effect of an anti-TNFα monoclonal antibody (cA2) on bone marrow stem/progenitor cell reserve and function and on bone marrow stromal cell function in patients with myelodysplastic syndromes” (39.000 £) (2003-2006).

6FP, E.U. Integrated Program. “Adult mesenchymal stem cells engineering for connective tissue disorders from the bench to the bedside (GENOSTEM_/ LSHB-CT-2003-503961)”. (254.000 €) (2004-2007).

General Secretariat of Research and Technology, Greece, PENED 03ED072. “Study of MSCs in MDS” (56.000 €) (2006-2009).

General Secretariat of Research and Technology, Greece, 09SYN-13-880. “Study of Chronic Idiopathic Neutropenia” (240.000 €) (2011-2015).

7FP, TransPot, REGPOT-2011-1.“Enhancing University of Crete Medical School Scientific Excellence and Translational Research Potential in Human Diseases” (3.000.000 €) (2012-2015).

General Secretariat of Research and Technology, Greece, “SYNERGASIA 11SYN_10_668”. «Generation of a Public Umbilical Cord Blood Bank in Crete». (640.000 €) (2013-2015).

Cost Action BM 1404. European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells (Mye-EUNITER) (2014-2018).

 

RESEARCH INTERESTS

Chronic Idiopathic Neutropenia; Mesenchymal Stem Cells; Myelodysplastic Syndromes; Bone Marrow Failure ; Regenerative Medicine.

 

PUBLICATIONS (PUBMED)
  1. Mastrodemou S, Stalika E, Vardi A, Gemenetzi K, Spanoudakis M, Karypidou M, Mavroudi I, Hadzidimitriou A, Stavropoulos-Giokas C, Papadaki HA, Stamatopoulos K. Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors. Leuk Lymphoma. 2017 May 23:1-8. doi: 10.1080/10428194.2017.1324154. [Epub ahead of print]
  2.  Batsali AK, Pontikoglou C, Koutroulakis D, Pavlaki KI, Damianaki A, Mavroudi I, Alpantaki K, Kouvidi E, Kontakis G, Papadaki HA. Differential expression of cell cycle and WNT pathway-related genes accounts for differences in the growth and differentiation potential of Wharton's jelly and bone marrow-derived mesenchymal stem cells. Stem Cell Res Ther. 2017 Apr 26;8(1):102. doi: 10.1186/s13287-017-0555-9.
  3. Papadantonakis P, Kaparou M, Papadaki HA, Marinos L, Krasagakis K. Multiple cutaneous reticulohistiocytosis with T-cell large granular lymphocyte clonopathy. Australas J Dermatol. 2017 Apr 4. doi: 10.1111/ajd.12608. [Epub ahead of print]
  4. Chatzinikolaidou M, Pontikoglou C, Terzaki K, Kaliva M, Kalyva A, Papadaki E, Vamvakaki M, Farsari M. Recombinant human bone morphogenetic protein 2 (rhBMP-2) immobilized on laser-fabricated 3D scaffolds enhance osteogenesis.Colloids Surf B Biointerfaces. 2016 Oct 13;149:233-242. doi: 10.1016/j.colsurfb.2016.10.027. [Epub ahead of print]
  5. Kalpadakis C, Pangalis GA, Vassilakopoulos TP, Roumelioti M, Sachanas S, Korkolopoulou P, Koulieris E, Moschogiannis M, Yiakoumis X, Tsirkinidis P, Pontikoglou C, Rondoyianni D, Papadaki HA, Panayiotidis P, Angelopoulou MK. Detection of L265P MYD-88 mutation in a series of clonal B-cell lymphocytosis of marginal zone origin (CBL-MZ). Hematol Oncol. 2016 Oct 13. doi: 10.1002/hon.2361. [Epub ahead of print]
  6. Steurer M, Quittet P, Papadaki HA, Selleslag D, Viallard JF, Kaiafa G, Janssens A, Kozak T, Wadenvik H, Schoonen M, Belton L, Kreuzbauer G. A large observational study of patients with primary immune thrombocytopenia receiving romiplostim in European clinical practice. Eur J Haematol. 2016 Aug 25. doi: 10.1111/ejh.12807. [Epub ahead of print]
  7. Damianaki A, Stagakis E, Mavroudi I, Spanoudakis M, Koutala H, Papadogiannis F, Kanellou P, Pontikoglou C, Papadaki HA. Minor populations of paroxysmal nocturnal haemoglobinuria type cells in patients with chronic idiopathic neutropenia. Eur J Haematol. 2016 Dec;97:538-546 
  8. Kalpadakis C, Pangalis GA, Sachanas S, Rontogianni D, Korkolopoulou P, Milionis V, Vassilakopoulos TP, Papadaki HA, Angelopoulou MK. No evidence of splenic disease in patients with splenic marginal zone lymphoma undergoing splenectomy for autoimmune hemolytic anemia after monotherapy with rituximab. Leuk Lymphoma. 2016 Apr 15:1-4. [Epub ahead of print]
  9. Kouvidi E, Stratigi A, Batsali A, Mavroudi I, Mastrodemou S, Ximeri M, Papadaki HA, Pontikoglou CG.Cytogenetic evaluation of mesenchymal stem/stromal cells from patients with myelodysplastic syndromes at different time-points during ex vivo expansion. Leuk Res. 2016 Feb 18;43:24-32.
  10. Palmblad J, Nilsson CC, Höglund P, Papadaki HA. How we diagnose and treat neutropenia in adults. Expert Rev Hematol. 2016 Feb 16:1-9.
  11. Miltiades P, Lamprianidou E, Vassilakopoulos TP, Papageorgiou SG, Galanopoulos AG, Kontos CK, Adamopoulos PG, Nakou E, Vakalopoulou S, Garypidou V, Papaioannou M, Hatjiharissi E, Papadaki HA, Spanoudakis E, Pappa V, Scorilas A, Tsatalas C, Kotsianidis I; Hellenic MDS Study Group. The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine. Clin Cancer Res. 2015 Dec 23. [Epub ahead of print]
  12. Kalyva A, Marketou ME, Parthenakis FI, Pontikoglou C, Kontaraki JE, Maragkoudakis S, Petousis S, Chlouverakis G, Papadaki HA, Vardas PE. Endothelial progenitor cells as markers of severity in hypertrophic cardiomyopathy. Eur J Heart Fail. 2016 Feb;18(2):179-84.
  13. Kyritsi EM, Yiakoumis X, Pangalis GA, Pontikoglou C, Pyrovolaki K, Kalpadakis C, Mavroudi I, Koutala H, Mastrodemou S, Vassilakopoulos TP, Vaiopoulos G, Diamanti-Kandarakis E, Papadaki HA, Angelopoulou MK. High Frequency of Thyroid Disorders in Patients Presenting With Neutropenia to an Outpatient Hematology Clinic STROBE-Compliant Article. Medicine (Baltimore). 2015 Jun;94(23):e886.
  14. Marketou ME, Parthenakis FI, Kalyva A, Pontikoglou C, Maragkoudakis S, Kontaraki JE, Zacharis EA, Patrianakos A, Chlouverakis G, Papadaki HA, Vardas PE. Circulating mesenchymal stem cells in patients with hypertrophic cardiomyopathy. Cardiovasc Pathol. 2015;24(3):149-53.
  15. Chatzinikolaidou M, Rekstyte S, Danilevicius P, Pontikoglou C, Papadaki HΑ, Farsari M, Vamvakaki M. Adhesion and growth of human bone marrow mesenchymal stem cells on precise-geometry 3D organic-inorganic composite scaffolds for bone repair Mater Sci Eng C Mater Biol Appl. 2015;48:301-9.
  16. Levidou G, Sachanas S, Pangalis GA, Kalpadakis C, Yiakoumis X, Moschogiannis M, Sepsa A, Lakiotaki E, Milionis V, Kyrtsonis MC, Vassilakopoulos TP, Tsirkinidis P, Kontopidou F, Kokoris S, Siakantaris M, Angelopoulou M, Papadaki HΑ, Kavantzas N, Panayiotidis P, Patsouris E, Korkolopoulou P.Immunohistochemical analysis of IL-6, IL-8/CXCR2 axis,  Tyr p-STAT-3, and SOCS-3 in lymph nodes from patients with chronic lymphocytic leukemia: correlation between microvascular characteristics and prognostic significance. Biomed Res Int. 2014; 2014:251479. doi: 10.1155/2014/251479. Epub 2014 May 5.
  17. Vassilakopoulos TP, Pangalis GA, Chatziioannou S, Papageorgiou S, Angelopoulou MK, Galani Z, Kourti G, Prassopoulos V, Leonidopoulou T, Terpos E, Dimopoulou MN, Sachanas S, Kalpadakis C, Konstantinidou P, Boutsis D, Stefanoudaki E, Kyriazopoulou L, Siakantaris MP, Kyrtsonis MC, Variami E, Kotsianidis I, Symeonidis A, Michali E, Katodritou E, Kokkini G, Tsatalas C, Papadaki HΑ, Dimopoulos MA, Sotiropoulos V, Pappa V, Karmiris T, Meletis J, Apostolidis J, Datseris I, Panayiotidis P, Konstantopoulos K, Roussou P, Rondogianni P. PET/CT in primary mediastinal large B-cell lymphoma responding to rituximab-CHOP: An analysis of 106 patients regarding prognostic significance and implications for subsequent radiotherapy. Leukemia. 2015. doi: 10.1038/leu.2015.120.
  18. Sachanas S, Pangalis GA, Kalpadakis C, Levidou G, Yiakoumis X, Moschogiannis M, Kyrtsonis MC, Vassilakopoulos TP, Tsirkinidis P, Siakantaris M, Spiliadi C, Karagianni E, Korkolopoulou P, Rontogianni D, Papadaki H, Panayiotidis P, Angelopoulou M. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) with concurrent high grade component at diagnosis: clinico-pathologic features and treatment strategy. Leuk Lymphoma. 2015 Nov;56:3230-2.
  19. Marketou ME, Parthenakis FI, Kalyva A, Pontikoglou C, Maragkoudakis S, Kontaraki JE, Zacharis EA, Chlouverakis G, Patrianakos A, Papadaki HA, Vardas PE.Increased mobilization of mesenchymal stem cells in patients with essential hypertension: the effect of left ventricular hypertrophy. J Clin Hypertens . 2014;16(12):883-8.
  20. Kalpadakis C, Pangalis GA, Sachanas S, Vassilakopoulos TP, Kyriakaki S, Korkolopoulou P, Koulieris E, Moschogiannis M, Yiakoumis X, Tsirkinidis P, Kyrtsonis MC, Levidou G, Papadaki HA, Panayiotidis P, Angelopoulou MK. New insights into monoclonal B-cell lymphocytosis. Biomed Res Int. 2014;2014:258917.
  21. Kalpadakis C, Pangalis GA, Vassilakopoulos TP, Kyriakaki S, Yiakoumis X, Sachanas S, Moschogiannis M, Tsirkinidis P, Korkolopoulou P, Papadaki HA, Angelopoulou MK.Clinical aspects of malt lymphomas. Curr Hematol Malig Rep. 2014 Sep;9(3):262-72.
  22. Zeidler C, Grote UA, Nickel A, Brand B, Carlsson G, Cortesão E, Dufour C, Duhem C, Notheis G, Papadaki HA, Tamary H, Tjønnfjord GE, Tucci F, Van Droogenbroeck J, Vermylen C, Voglova J, Xicoy B, Welte K. Outcome and management of pregnancies in severe chronic neutropenia patients by the European Branch of the Severe Chronic Neutropenia International Registry. Haematologica. 2014 Aug;99(8):1395-402.
  23. Palmblad J, Dufour C, Papadaki HA. How we diagnose neutropenia in the adult and elderly patient. Haematologica. 2014 Jul;99(7):1130-3.
  24. Marketou ME, Kalyva A, Parthenakis FI, Pontikoglou C, Maragkoudakis S, Kontaraki JE, Chlouverakis G, Zacharis EA, Patrianakos A, Papadaki HA, Vardas PE. Circulating endothelial progenitor cells in hypertensive patients with increased arterial stiffness. J Clin Hypertens. 2014 Apr;16(4):295-300.PMID: 24641802
  25. Pavlaki K, Pontikoglou CG, Demetriadou A, Batsali AK, Damianaki A, Simantirakis E, Kontakis M, Galanopoulos A, Kotsianidis I, Kastrinaki MC, Papadaki HA. Impaired Proliferative Potential of Bone Marrow Mesenchymal Stromal Cells in Patients with Myelodysplastic Syndromes Is Associated with Abnormal WNT Signaling Pathway. Stem Cells Dev. 2014 Jul 15;23(14):1568-81.
  26. Miltiades P, Lamprianidou E, Vassilakopoulos TP, Papageorgiou SG, Galanopoulos AG, Vakalopoulou S, Garypidou V, Papaioannou M, Hadjiharissi E, Pappa V, Papadaki HA, Spanoudakis E, Tsatalas K, Kotsianidis I. Expression of CD25 antigen on CD34+ cells is an independent predictor of outcome in late-stage MDS patients treated with azacitidine. Blood Cancer J. 2014 Feb 28;4:e187.
  27. Kalpadakis C, Pangalis GA, Angelopoulou MK, Sachanas S, Kontopidou F, Moschogiannis M, Ximeri M, Tsirkinidis P, Yiakoumis X, Papadaki HA, Vassilakopoulos TP. Validation of the simplified prognostic score for splenic marginal zone lymphoma of the Splenic Marginal Zone Lymphoma Working Group. Leuk Lymphoma. 2014 2014 Nov;55(11):2640-2.Mar 25.
  28. c-JUN N-terminal kinase (JNK) is activated and contributes to tumor cell proliferation in classical Hodgkin lymphoma. Leventaki V, Drakos E, Karanikou M, Psatha K, Lin P, Schlette E, Eliopoulos A, Vassilakopoulos TP, Papadaki HA, Patsouris E, Medeiros LJ, Rassidakis GZ. Hum Pathol. 2014 Mar;45(3):565-72.
  29. Kastrinaki MC, Pavlaki K, Batsali AK, Kouvidi E, Mavroudi I, Pontikoglou C, Papadaki HA. Mesenchymal stem cells in immune-mediated bone marrow failure syndromes. Clin Dev Immunol. 2013;2013:265608.
  30. Xochelli A, Kalpadakis C, Gardiner A, Baliakas P, Vassilakopoulos TP, Mould S, Davis Z, Stalika E, Kanellis G, Angelopoulou MK, McIver-Brown N, Ibbotson R, Sachanas S, Korkolopoulou P, Athanasiadou A, Anagnostopoulos A, Papadaki HA, Papadaki T, Stamatopoulos K, Pangalis GA, Oscier D. Clonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with a marginal-zone origin: is this a distinct entity? Blood. 2014 Feb 20;123(8):1199-206.
  31. Treatment of splenic marginal zone lymphoma with rituximab monotherapy: progress report and comparison with splenectomy. Kalpadakis C, Pangalis GA, Angelopoulou MK, Sachanas S, Kontopidou FN, Yiakoumis X, Kokoris SI, Dimitriadou EM, Dimopoulou MN, Moschogiannis M, Korkolopoulou P, Kyrtsonis MC, Siakantaris MP, Papadaki T, Tsaftaridis P, Plata E, Papadaki HE, Vassilakopoulos TP. Oncologist. 2013;18(2):190-7.
  32. Manousou P, Kolios G, Drygiannakis I, Koulentaki M, Pyrovolaki K, Voumvouraki A, Notas G, Bourikas L, Papadaki HA, Kouroumalis E. CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid. Clin Exp Immunol. 2013 Apr;172(1):9-15.
  33. Velegraki M, Papakonstanti E, Mavroudi I, Psyllaki M, Tsatsanis C, Oulas A, Iliopoulos I, Katonis P, Papadaki HA. Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production. Haematologica. 2013 Aug;98(8):1206-15.
  34. Batsali AK, Kastrinaki MC, Papadaki HA, Pontikoglou C. Mesenchymal stem cells derived from Wharton's Jelly of the umbilical cord: biological properties and emerging clinical applications. Curr Stem Cell Res Ther. 2013 Mar;8(2):144-55. Review.
  35. Pontikoglou C, Kastrinaki MC, Klaus M, Kalpadakis C, Katonis P, Alpantaki K, Pangalis GA, Papadaki HA. Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia. Stem Cells Dev. 2013 May 1;22(9):1329-41.
  36. Mavroudi I, Papadaki HA. Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia. Clin Dev Immunol. 2012;2012:123789. doi: 10.1155/2012/123789. Epub 2012 Aug 26. Review.
  37. Mastrodemou S, Vazgiourakis V, Velegraki M, Pavlaki K, Goulielmos GN, Papadaki HA. Clonal patterns of X-chromosome inactivation in peripheral blood cells of female patients with chronic idiopathic neutropenia. Haematologica. 2012 Dec;97(12):1931-3.
  38. Antoniou KM, Margaritopoulos GA, Proklou A, Karagiannis K, Lasithiotaki I, Soufla G, Kastrinaki MC, Spandidos DA, Papadaki HA, Siafakas NM. Investigation of Telomerase/Telomeres system in Bone Marrow Mesenchymal Stem Cells derived from IPF and RA-UIP. J Inflamm (Lond). 2012 Jul 2;9(1):27.
  39. Pavlaki KI, Kastrinaki MC, Klontzas M, Velegraki M, Mavroudi I, Papadaki HA. Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia. Haematologica. 2012 May;97(5):743-50.
  40. Velegraki M, Koutala H, Tsatsanis C, Papadaki HA. Increased levels of the high mobility group box 1 protein sustain the inflammatory bone marrow microenvironment in patients with chronic idiopathic neutropenia via activation of toll-like receptor 4. J Clin Immunol. 2012 Apr;32(2):312-22.
  41. Mavroudi I, Papadaki HA. The role of CD40/CD40 ligand interactions in bone marrow granulopoiesis. ScientificWorldJournal. 2011;11:2011-9.
  42. Gemetzi C, Mavroudi I, Koutala H, Velegraki M, Choulaki C, Damianaki A, Pontikoglou C, Papadaki HA. Lymphopenia in patients with chronic idiopathic neutropenia is associated with decreased number of T-lymphocytes containing T-cell receptor excision circles. Eur J Haematol. 2012 Mar;88(3):210-23.
  43. Pontikoglou C, Kalpadakis C, Papadaki HA. Pathophysiologic mechanisms and management of neutropenia associated with large granular lymphocytic leukemia. Expert Rev Hematol. 2011 Jun;4(3):317-28.
  44. Mavroudi I, Papadaki V, Pyrovolaki K, Katonis P, Eliopoulos AG, Papadaki HA. The CD40/CD40 ligand interactions exert pleiotropic effects on bone marrow granulopoiesis. J Leukoc Biol. 2011 May;89(5):771-83.
  45. Pontikoglou C, Deschaseaux F, Sensebé L, Papadaki HA. Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation. Stem Cell Rev. 2011 Sep;7(3):569-89.
  46. Klaus M, Psaraki A, Mastrodemou S, Pyrovolaki K, Mavroudi I, Kalpadakis C, Papadaki HA. Evaluation of TET2 deletions in myeloid disorders: a fluorescence in situ hybridization analysis of 109 cases. Leuk Res. 2011 Mar;35(3):413-5.
  47. Manousou P, Kolios G, Valatas V, Drygiannakis I, Bourikas L, Pyrovolaki K, Koutroubakis I, Papadaki HA, Kouroumalis E. Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies. Clin Exp Immunol. 2010 Nov;162(2):337-47.
  48. Stavroulaki E, Kastrinaki MC, Pontikoglou C, Eliopoulos D, Damianaki A, Mavroudi I, Pyrovolaki K, Katonis P, Papadaki HA. Mesenchymal stem cells contribute to the abnormal bone marrow microenvironment in patients with chronic idiopathic neutropenia by overproduction of transforming growth factor-β1. Stem Cells Dev. 2011 Aug;20(8):1309-18.
  49. Spanoudakis M, Koutala H, Ximeri M, Pyrovolaki K, Stamatopoulos K, Papadaki HA. T-cell receptor Vβ repertoire analysis in patients with chronic idiopathic neutropenia demonstrates the presence of aberrant T-cell expansions. Clin Immunol. 2010 Dec;137(3):384-95.
  50. Mavroudi I, Pyrovolaki K, Pavlaki K, Kozana A, Psyllaki M, Kalpadakis C, Pontikoglou C, Papadaki HA. Effect of the nonpeptide thrombopoietin receptor agonist eltrombopag on megakaryopoiesis of patients with lower risk myelodysplastic syndrome. Leuk Res. 2011 Mar;35(3):323-8.
  51. Kastrinaki MC, Pontikoglou C, Klaus M, Stavroulaki E, Pavlaki K, Papadaki HA. Biologic characteristics of bone marrow mesenchymal stem cells in myelodysplastic syndromes. Curr Stem Cell Res Ther. 2011 Jun;6(2):122-30. Review.
  52. Pontikoglou C, Papadaki HA. Idiosyncratic drug-induced agranulocytosis: the paradigm of deferiprone. Hemoglobin. 2010 Jun;34(3):291-304.
  53. Antoniou KM, Papadaki HA, Soufla G, Kastrinaki MC, Damianaki A, Koutala H, Spandidos DA, Siafakas NM. Investigation of bone marrow mesenchymal stem cells (BM MSCs) involvement in Idiopathic Pulmonary Fibrosis (IPF). Respir Med. 2010 Oct;104(10):1535-42.
  54. Klaus M, Stavroulaki E, Kastrinaki MC, Fragioudaki P, Giannikou K, Psyllaki M, Pontikoglou C, Tsoukatou D, Mamalaki C, Papadaki HA. Reserves, functional, immunoregulatory, and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes. Stem Cells Dev. 2010 Jul;19(7):1043-54.
  55. Ximeri M, Galanopoulos A, Klaus M, Parcharidou A, Giannikou K, Psyllaki M, Symeonidis A, Pappa V, Kartasis Z, Liapi D, Hatzimichael E, Kokoris S, Korkolopoulou P, Sambani C, Pontikoglou C, Papadaki HA; Hellenic MDS Study Group. Effect of lenalidomide therapy on hematopoiesis of patients with myelodysplastic syndrome associated with chromosome 5q deletion. Haematologica. 2010 Mar;95(3):406-14.
  56. Nakou M, Katsikas G, Sidiropoulos P, Bertsias G, Papadimitraki E, Raptopoulou A, Koutala H, Papadaki HA, Kritikos H, Boumpas DT. Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response. Arthritis Res Ther. 2009;11(4):R131.
  57. Eliopoulos DG, Mavroudi I, Pontikoglou C, Ximeri M, Stavroulaki E, Pyrovolaki K, Velegraki M, Spanoudakis M, Goulielmos G, Papadaki HA. The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. Eur J Haematol. 2009 Dec 1;83(6):535-40.
  58. Kalpadakis C, Pangalis GA, Dimitriadou E, Angelopoulou MK, Siakantaris MP, Kyrtsonis MC, Ximeris M, Tzenou T, Sahanas S, Yiakoumis X, Papadaki HA, Panayiotidis P, Vassilakopoulos T. Mutation analysis of IgVH genes in splenic marginal zone lymphomas: correlation with clinical characteristics and outcome. Anticancer Res. 2009;29(5):1811-6
  59. Kalpadakis C, Pangalis GA, Vassilakopoulos TP, Kyrtsonis MC, Siakantaris MP, Kontopidou FN, Korkolopoulou P, Bobotsis P, Sahanas S, Tzenou T, Anagnostou D, Dimitriadou E, Yiakoumis X, Patsouris E, Roussou P, Panayiotidis P, Papadaki HA, Angelopoulou MK. Non-gastric extra-nodal marginal zone lymphomas--a single centre experience on 76 patients. Leuk Lymphoma. 2008 Dec;49(12):2308-15.
  60. Polioudaki H, Kastrinaki MC, Papadaki HA, Theodoropoulos PA. Microtubule-interacting drugs induce moderate and reversible damage to human bone marrow mesenchymal stem cells. Cell Prolif. 2009 Aug;42(4):434-47.
  61. Antoniou KM, Papadaki HA, Soufla G, Siafakas NM. Short telomeres and treatment of pulmonary fibrosis: implications for early intervention. Am J Respir Crit Care Med. 2009 May 15;179(10):970.
  62. Pyrovolaki K, Mavroudi I, Sidiropoulos P, Eliopoulos AG, Boumpas DT, Papadaki HA. Increased expression of CD40 on bone marrow CD34+ hematopoietic progenitor cells in patients with systemic lupus erythematosus: contribution to Fas-mediated apoptosis. Arthritis Rheum. 2009 Feb;60(2):543-52.
  63. Kastrinaki MC, Papadaki HA. Mesenchymal stromal cells in rheumatoid arthritis: biological properties and clinical applications. Curr Stem Cell Res Ther. 2009 Jan;4(1):61-9.
  64. Roche S, Delorme B, Oostendorp RA, Barbet R, Caton D, Noel D, Boumediene K, Papadaki HA, Cousin B, Crozet C, Milhavet O, Casteilla L, Hatzfeld J, Jorgensen C, Charbord P, Lehmann S. Comparative proteomic analysis of human mesenchymal and embryonic stem cells: towards the definition of a mesenchymal stem cell proteomic signature. Proteomics. 2009 Jan;9(2):223-32.
  65. Papadaki HA, Pontikoglou C. Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia.Expert Rev Hematol. 2008 Dec;1(2):217-29.
  66. Non-gastric extra-nodal marginal zone lymphomas--a single centre experience on 76 patients. Kalpadakis C, Pangalis GA, Vassilakopoulos TP, Kyrtsonis MC, Siakantaris MP, Kontopidou FN, Korkolopoulou P, Bobotsis P, Sahanas S, Tzenou T, Anagnostou D, Dimitriadou E, Yiakoumis X, Patsouris E, Roussou P, Panayiotidis P, Papadaki E, Angelopoulou MK. Leuk Lymphoma. 2008 Dec;49(12):2308-15.
  67. Ziakas PD, Papadaki HA, Psyllaki M, Voulgarelis M. Anti-thrombopoietin antibodies suppress megakaryocytic colony formation in vitro in patients with systemic lupus erythaematosus. Ann Rheum Dis. 2008 Nov;67(11):1643-4.
  68. Kastrinaki MC, Andreakou I, Charbord P, Papadaki HA. Isolation of human bone marrow mesenchymal stem cells using different membrane markers: comparison of colony/cloning efficiency, differentiation potential, and molecular profile. Tissue Eng Part C Methods. 2008 Dec;14(4):333-9.
  69. Manousou P, Kolios G, Drygiannakis I, Pyrovolaki K, Bourikas L, Papadaki HA, Kouroumalis E. Expression of a splice variant of CXCR3 in Crohn's disease patients; indication for a lymphocyte--epithelial cell interaction. J Gastroenterol Hepatol. 2008 Dec;23(12):1823-33.
  70. Stavropoulou C, Sambani C, Rigana H, Georgakakos VN, Voutsinas G, Manola KN, Pantelias GE, Makropoulos V; Hellenic MDS Study Group. Low frequency of the glutathione-S-transferase T1-null genotype in patients with primary myelodysplastic syndrome and 5q deletion. Leukemia. 2008 Aug;22(8):1643-6.
  71. Stamatopoulos K, Papadaki T, Pontikoglou C, Athanasiadou I, Stavroyianni N, Bux J, Batsis I, Pyrovolaki K, Paterakis G, Anagnostou D, Anagnostopoulos A, Papadaki HA. Lymphocyte subpopulation imbalances, bone marrow hematopoiesis and histopathology in rituximab-treated lymphoma patients with late-onset neutropenia. Leukemia. 2008 Jul;22(7):1446-9.
  72. Roubelakis MG, Pappa KI, Bitsika V, Zagoura D, Vlahou A, Papadaki HA, Antsaklis A, Anagnou NP. Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev. 2007 Dec;16(6):931-52.
  73. Palmblad J, Papadaki HA. Chronic idiopathic neutropenias and severe congenital neutropenia.Curr Opin Hematol. 2008 Jan;15(1):8-14. Review.
  74. Pyrovolaki K, Mavroudi I, Papadantonakis N, Velegraki M, Ximeri M, Kalpadakis C, Gvazava G, Klaus M, Eliopoulos GD, Papadaki HA. Transforming growth factor-beta1 affects interleukin-10 production in the bone marrow of patients with chronic idiopathic neutropenia. Eur J Haematol. 2007 Dec;79(6):531-8.
  75. Galanopoulos AG, Symeonidis A, Kourakli A, Papadaki EA, Tsaftaridis P, Terpos E, Aktipi A, Roussou P, Protopappa M, Pappaioannou M, Zikos P, Speletas M, Parcharidou A, Laoutaris N, Anagnostopoulos NI, Meletis J, Pangalis GA, Zoumbos N, Viniou N; Hellenic MDS Study Group. Prognostic significance of deletion of the long arm of chromosome 20 in patients with myelodysplastic syndrome (MDS): a study of the Greek MDS Study Group. Eur J Haematol. 2007 Jan;78(1):89-90.
  76. Kastrinaki MC, Sidiropoulos P, Roche S, Ringe J, Lehmann S, Kritikos H, Vlahava VM, Delorme B, Eliopoulos GD, Jorgensen C, Charbord P, Häupl T, Boumpas DT, Papadaki HA. Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis. Ann Rheum Dis. 2008 Jun;67(6):741-9.
  77. Repapinou Z, Karababa P, Boussiou M, Kafarakis V, Papadaki HA, Mavroudis D, Eliopoulos GD, Loutradi-Anagnostou A. An improved method for the diagnostic approach of alpha+-thalassaemia. Int J Lab Hematol. 2007 Feb;29(1):45-51.
  78. Froudarakis ME, Papadaki HA, Klimathianaki M, Damianaki A, Pougounias M, Kotsianidis I, Astoul P. Thoracoscopic talc poudrage decreases T-lymphocytes in the peripheral blood. Respir Med. 2007 Jun;101(6):1212-7. Epub 2006 Dec 19.
  79. Koumaki V, Damianaki A, Ximeri M, Pontikoglou C, Axioti F, Spanoudakis M, Eliopoulos GD, Papadaki HA. Pro-inflammatory bone marrow milieu in patients with chronic idiopathic neutropenia is associated with impaired local production of interleukin-10. Br J Haematol. 2006 Nov;135(4):570-3.
  80. Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos GD, Papadaki HA. Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. Exp Hematol. 2006 Oct;34(10):1312-22.
  81. Psyllaki M, Damianaki A, Gemetzi C, Pyrovolaki K, Eliopoulos GD, Papadaki HA. Impaired megakaryopoiesis in patients with chronic idiopathic neutropenia is associated with increased transforming growth factor beta1 production in the bone marrow. Br J Haematol. 2006 Sep;134(6):624-31.
  82. Boula A, Voulgarelis M, Giannouli S, Katrinakis G, Psyllaki M, Pontikoglou C, Markidou F, Eliopoulos GD, Papadaki HA. Effect of cA2 anti-tumor necrosis factor-alpha antibody therapy on hematopoiesis of patients with myelodysplastic syndromes. Clin Cancer Res. 2006 May 15;12(10):3099-108.
  83. Tsoumakidou M, Tzanakis N, Papadaki HA, Koutala H, Siafakas NM. Isolation of myeloid and plasmacytoid dendritic cells from human bronchoalveolar lavage fluid. Immunol Cell Biol. 2006 Jun;84(3):267-73.
  84. Papadaki HA, Damianaki A, Pontikoglou C, Pyrovolaki K, Eliopoulos DG, Stavroulaki E, Eliopoulos GD. Increased levels of soluble flt-3 ligand in serum and long-term bone marrow culture supernatants in patients with chronic idiopathic neutropenia. Br J Haematol. 2006 Mar;132(5):637-9.
  85. Lygnos MC, Pappa KI, Papadaki HA, Relakis C, Koumantakis E, Anagnou NP, Eliopoulos GD. Changes in maternal plasma levels of VEGF, bFGF, TGF-beta1, ET-1 and sKL during uncomplicated pregnancy, hypertensive pregnancy and gestational diabetes. In Vivo. 2006 Jan-Feb;20(1):157-63.
  86. Papadaki HA, Pontikoglou C, Eliopoulos DG, Pyrovolaki K, Spyridaki R, Eliopoulos GD. Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly. Am J Hematol. 2006 Feb;81(2):142-4.
  87. Mantadakis E, Pontikoglou C, Papadaki HA, Aggelidakis G, Samonis G. Fatal Fournier's gangrene in a young adult with acute lymphoblastic leukemia.Pediatr Blood Cancer. 2007 Nov;49(6):862-4.
  88. Papadaki HA, Pontikoglou C, Stavroulaki E, Eliopoulos DG, Mavroudi I, Spanoudakis M, Eliopoulos GD. Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. Ann Hematol. 2006 Mar;85(3):170-3
  89. Papadaki HA, Tsagournisakis M, Mastorodemos V, Pontikoglou C, Damianaki A, Pyrovolaki K, Stamatopoulos K, Fassas A, Plaitakis A, Eliopoulos GD. Normal bone marrow hematopoietic stem cell reserves and normal stromal cell function support the use of autologous stem cell transplantation in patients with multiple sclerosis. Bone Marrow Transplant. 2005 Dec;36(12):1053-63.
  90. Mavrogianni D, Tsaftaridis P, Terpos E, Symeonidis A, Galanopoulus A, Papadaki EA, Zoumbos N, Meletis J, Pangalis GA, Viniou N. Macrophage Inflammatory Protein-1 alpha (MIP-1alpha) is over-expressed in a cohort of patients with myelodysplastic syndromes. Eur J Haematol. 2005 Jul;75(1):85-6.
  91. Pontikoglou C, Fragos C, Kolyvaki E, Samonis G, Eliopoulos GD, Papadaki HA. Multiple myeloma involving the central nervous system: a report of two cases with unusual manifestations. Leuk Lymphoma. 2005 May;46(5):737-41.
  92. Papadaki HA, Stamatopoulos K, Damianaki A, Gemetzi C, Anagnostopoulos A, Papadaki T, Eliopoulos AG, Eliopoulos GD. Activated T-lymphocytes with myelosuppressive properties in patients with chronic idiopathic neutropenia. Br J Haematol. 2005 Mar;128(6):863-76.
  93. Papadaki HA, Pontikoglou C, Stavroulaki E, Minadakis G, Eliopoulos DA, Pyrovolaki K, Skordilis P, Eliopoulos GD. High prevalence of Helicobacter pylori infection and monoclonal gammopathy of undetermined significance in patients with chronic idiopathic neutropenia. Ann Hematol. 2005 May;84(5):317-20.
  94. Ponchel F, Verburg RJ, Bingham SJ, Brown AK, Moore J, Protheroe A, Short K, Lawson CA, Morgan AW, Quinn M, Buch M, Field SL, Maltby SL, Masurel A, Douglas SH, Straszynski L, Fearon U, Veale DJ, Patel P, McGonagle D, Snowden J, Markham AF, Ma D, van Laar JM, Papadaki HA, Emery P, Isaacs JD. Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia. Arthritis Res Ther. 2005;7(1):R80-92. Epub 2004 Nov 16.
  95. Christoforidou AV, Papadaki HA, Margioris AN, Eliopoulos GD, Tsatsanis C. Expression of the Tpl2/Cot oncogene in human T-cell neoplasias. Mol Cancer. 2004 Dec 3;3(1):34.
  96. Papadaki HA, Tsatsanis C, Christoforidou A, Malliaraki N, Psyllaki M, Pontikoglou C, Miliaki M, Margioris AN, Eliopoulos GD. Alendronate reduces serum TNFalpha and IL-1beta, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis. J Bone Miner Metab. 2004;22(6):577-87.
  97. Megalakaki A, Mitsouli C, Pontikoglou C, Iakovidou J, Koumaki V, Eliopoulos GD, Papadaki HA. Chronic idiopathic neutropenia preceding polymyalgia rheumatica and acute myeloid leukemia. Ann Hematol. 2004 Dec;83(12):791-2. Epub 2004 Aug 25. No abstract available.
  98. Papadaki HA, Kosteas T, Gemetzi C, Damianaki A, Anagnou NP, Eliopoulos GD. Acute myeloid/NK precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia. Ann Hematol. 2004 Jun;83(6):345-8.
  99. Papadaki HA, Kosteas T, Gemetzi C, Christoforidou A, Anagnou NP, Eliopoulos GD. Low serum gamma-glutamyltranspeptidase (GGT) in patients with chronic idiopathic neutropenia is not implicated in the pathophysiology of the disease. Haematologica. 2003 Nov;88(11):ELT32.
  100. Papadaki HA, Eliopoulos GD. The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure. Cell Cycle. 2003 Sep-Oct;2(5):447-51.
  101. Papadaki HA. Autoreactive T-lymphocytes are implicated in the pathogenesis of bone marrow failure in patients with systemic lupus erythematosus. Leuk Lymphoma. 2003 Aug;44(8):1301-7.
  102. Koumaki V, Papadaki HA, Stefanaki K, Damianaki A, Gemetzi C, Katonis P, Vrentzos G, Eliopoulos GD. Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia. Ann Hematol. 2003 Oct;82(10):641-5.
  103. Papadaki HA, Skordilis P, Minadakis G, Roussomoustakaki M, Katrinakis G, Psyllaki M, Tzardi M, Kouroumalis E, Eliopoulos GD. Complete regression of primary gastric plasmacytoma following Helicobacter pylori eradication. Ann Hematol. 2003 Sep;82(9):589-92.
  104. Person RE, Li FQ, Duan Z, Benson KF, Wechsler J, Papadaki HA, Eliopoulos G, Kaufman C, Bertolone SJ, Nakamoto B, Papayannopoulou T, Grimes HL, Horwitz M. Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat Genet. 2003 Jul;34(3):308-12.
  105. Papadaki HA, Xylouri I, Katrinakis G, Foudoulakis A, Kritikos HD, Stathopoulos EN, Boumpas DT, Eliopoulos GD. Non-Hodgkin's lymphoma in patients with systemic lupus erythematosus.Leuk Lymphoma. 2003 Feb;44(2):275-9.
  106. Papadaki HA, Horwitz M, Coulocheri SA, Person RA, Benson KF, Eliopoulos GD. Low levels of serum elastase are not associated with mutations in ELA-2 elastase encoding gene in chronic idiopathic neutropenia. Blood. 2003 Apr 1;101(7):2898-9.
  107. Papadaki HA, Eliopoulos AG, Kosteas T, Gemetzi C, Damianaki A, Koutala H, Bux J, Eliopoulos GD. Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood. 2003 Apr 1;101(7):2591-600.
  108. Papadaki HA, Michelakaki H, Bux J, Eliopoulos GD. Severe autoimmune neutropenia associated with bone marrow sea-blue histiocytosis. Br J Haematol. 2002 Sep;118(4):931.
  109. Papadaki HA, Marsh JC, Eliopoulos GD. Bone marrow stem cells and stromal cells in autoimmune cytopenias. Leuk Lymphoma. 2002 Apr;43(4):753-60. Review.
  110. Papadaki HA, Kritikos HD, Valatas V, Boumpas DT, Eliopoulos GD. Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy. Blood. 2002 Jul 15;100(2):474-82.
  111. Palmblad J, Papadaki HA, Eliopoulos G. Acute and chronic neutropenias. What is new?J Intern Med. 2001 Dec;250(6):476-91.
  112. Papadaki HA, Kritikos HD, Gemetzi C, Koutala H, Marsh JC, Boumpas DT, Eliopoulos GD. Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. Blood. 2002 Mar 1;99(5):1610-9. Erratum in: Blood. 2007 May 15;109(10):4180.
  113. Papadaki HA, Gibson FM, Psyllaki M, Gordon-Smith EC, Marsh JC, Eliopoulos GD. Assessment of bone marrow stem cell reserve and function and stromal cell function in patients with severe congenital neutropenia. Eur J Haematol. 2001 Oct;67(4):245-51.
  114. Papadaki HA, Kosteas T, Gemetzi C, Alexandrakis M, Psyllaki M, Eliopoulos GD. Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor. Ann Hematol. 2002 Jan;81(1):50-4. Epub 2001 Dec 14.
  115. Papadaki HA, Boumpas DT, Gibson FM, Jayne DR, Axford JS, Gordon-Smith EC, Marsh JC, Eliopoulos GD. Increased apoptosis of bone marrow CD34(+) cells and impaired function of bone marrow stromal cells in patients with systemic lupus erythematosus. Br J Haematol. 2001 Oct;115(1):167-74.
  116. Papadaki HA, Palmblad J, Eliopoulos GD. Non-immune chronic idiopathic neutropenia of adult: an overview. Eur J Haematol. 2001 Jul;67(1):35-44. Review.
  117. Papadaki HA, Charoulakis NZ, Eliopoulos DG, Psyllaki M, Eliopoulos GD. Patients with non-immune chronic idiopathic neutropenia syndrome have increased splenic volume on ultrasonography. Clin Lab Haematol. 2001 Apr;23(2):111-7.
  118. Papadaki HA, Eliopoulos DG, Valatas V, Eliopoulos GD. Anemia of chronic disease is the more frequent type of anemia seen in patients with chronic idiopathic neutropenia of adults. Ann Hematol. 2001 Apr;80(4):195-200.
  119. Papadaki HA, Eliopoulos DG, Ponticoglou C, Eliopoulos GD. Increased frequency of monoclonal gammopathy of undetermined significance in patients with nonimmune chronic idiopathic neutropenia syndrome. Int J Hematol. 2001 Apr;73(3):339-45.
  120. Papadaki HA, Psyllaki M, Eliopoulos DG, Tsiroyianni A, Eliopoulos GD. Increased frequency and specific reactivity of serum antinuclear antibodies in patients with nonimmune chronic idiopathic neutropenia of adults. Acta Haematol. 2001;105(1):13-20.
  121. Papadaki HA, Eliopoulos GD, Coulocheri SA, Spyropoulou M, Stavropoulos-Giokas C. Increased frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults. Blood. 2001 Jan 15;97(2):580-1.
  122. Papadaki HA, Chatzivassili A, Stefanaki K, Koumaki V, Kanavaros P, Eliopoulos GD. Morphologically defined myeloid cell compartments, lymphocyte subpopulations, and histological findings of bone marrow in patients with nonimmune chronic idiopathic neutropenia of adults. Ann Hematol. 2000 Oct;79(10):563-70.
  123. Papadaki HA, Coulocheri S, Eliopoulos GD. Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines. Am J Hematol. 2000 Dec;65(4):271-7.
  124. Papadaki HA, Palmblad J, Kapsimali V, Anagnou NP, Eliopoulos GD. Increased serum IgA and decreased IgG3 strongly correlate with increased serum TGF-beta1 levels in patients with nonimmune chronic idiopathic neutropenia of adults. Eur J Haematol. 2000 Oct;65(4):237-44.
  125. Papadaki HA, Gibson FM, Rizzo S, Gordon-Smith EC, Marsh JC. Assessment of bone marrow stem cell reserve and function and stromal cell function in patients with autoimmune cytopenias.Blood. 2000 Nov 1;96(9):3272-5.
  126. Papadaki HA, Vardakis C, Vaiopoulos G, Nanas J, Eliopoulos GD. Extensive calcification of the pericardium in a patient with primary amyloidosis. Ann Hematol. 2000 Jul;79(7):405-6.
  127. Papadaki HA, Kouroumalis EA, Stefanaki K, Roussomoustakaki M, Daskalogiannaki ME, Reppa D, Eliopoulos GD. Retractile mesenteritis presenting as fever of unknown origin and autoimmune haemolytic anaemia.Digestion. 2000;61(2):145-8.
  128. Rizzo S, Scopes J, Elebute MO, Papadaki HA, Gordon-Smith EC, Gibson FM. Stem cell defect in aplastic anemia: reduced long term culture-initiating cells (LTC-IC) in CD34+ cells isolated from aplastic anemia patient bone marrow. Hematol J. 2002;3(5):230-6.
  129. Papadaki HA, Stefanaki K, Kanavaros P, Katonis P, Papastathi H, Valatas W, Stylianoy K, Eliopoulos GD. Epstein-Barr virus-associated high-grade anaplastic plasmacytoma in a renal transplant patient. Leuk Lymphoma. 2000 Jan;36(3-4):411-5.
  130. Papadaki HA, Giouremou K, Eliopoulos GD. Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF-beta1 by bone marrow stromal cells. Eur J Haematol. 1999 Sep;63(3):154-62.
  131. Papadaki HA, Xylouri I, Coulocheri S, Kalmanti M, Kafatos A, Eliopoulos GD. Prevalence of chronic idiopathic neutropenia of adults among an apparently healthy population living on the island of Crete.Ann Hematol. 1999 Jul;78(7):293-7.
  132. Kanavaros P, Stefanaki K, Rontogianni D, Darivianaki K, Vlychou M, Papadaki E, Eliopoulos G, Bakiri M, Matsouka C, Kakolyris S, Georgoulias V. Immunohistochemical detection of p53, mdm2, waf1/p21, and Ki67 proteins in bone marrow biopsies in myelodysplastic syndroms, acute myelogenous leukaemias and chronic myeloproliferative disorders. Clin Exp Pathol. 1999;47(5):231-8.
  133. Papadaki HA, Margioris AN, Miliaki M, Steriopoulos C, Valatas W, Eliopoulos GD. Chronic idiopathic neutropenia of adults is associated with decreased bone mineral density and alterations in bone turnover biochemical markers. Eur J Haematol. 1999;62(5):311-6.
  134. Papadaki HA, Eliopoulos GD. Selective loss of peripheral blood CD45RO+ T lymphocytes correlates with increased levels of serum cytokines and endothelial cell-derived soluble cell adhesion molecules in patients with chronic idiopathic neutropenia of adults. Ann Hematol. 1998 Oct;77(4):153-9.
  135. Papadaki HA, Eliopoulos GD. Enhanced neutrophil extravasation may be a contributing factor in the determination of neutropenia in patients with chronic idiopathic neutropenia of adults.Eur J Haematol. 1998 Oct;61(4):272-7.
  136. Papadaki HA, Xylouri I, Valatas W, Petinarakis J, Kontopoulou I, Eliopoulos GD. Severe acquired hemophilia A successfully treated with activated recombinant human factor VII. Ann Hematol. 1998 Sep;77(3):123-5.
  137. Vaiopoulos G, Boki K, Kapsimali V, Coulocheri S, Papadaki HA, Eliopoulos GD. Hemoglobin levels correlate with serum soluble CD23 and TNF-Rs concentrations in patients with rheumatoid arthritis. Haematologia (Budap). 1998;29(2):89-99.
  138. Papadaki HA, Coulocheri S, Xylouri I, Chatzivassili A, Konsolas J, Katrinakis G, Karkavitsas N, Eliopoulos GD. Defective natural killer cell activity of peripheral blood lymphocytes correlates with the degree of neutropenia in patients with chronic idiopathic neutropenia of adults. Ann Hematol. 1998 Mar-Apr;76(3-4):127-34.
  139. Kyriakou D, Papadaki H, Eliopoulos AG, Foudoulakis A, Alexandrakis M, Eliopoulos GD. Serum soluble IL-6 receptor concentrations correlate with stages of multiple myeloma defined by serum beta 2-microglobulin and C-reactive protein. Int J Hematol. 1997 Oct;66(3):367-71.
  140. Kyriakou D, Papadaki HA, Sakellariou D, Eliopoulos AG, Kapsimali V, Eliopoulos GD. Flow-cytometric analysis of peripheral blood lymphocytes in patients with chronic idiopathic neutropenia of adults. Ann Hematol. 1997 Sep;75(3):103-10.
  141. Papadaki H, Konsolas J, Chatzivassili A, Katrinakis G, Foudoulakis A, Markidou F, Alexandrakis M, Kyriakou D, Eliopoulos GD. Inhibition of mitogen-induced cellular cytotoxicity by serum from patients with multiple myeloma. Haematologia (Budap). 1997;28(3):123-30.
  142. Papadaki H, Kyriakou D, Foudoulakis A, Markidou F, Alexandrakis M, Eliopoulos GD. Serum levels of soluble IL-6 receptor in multiple myeloma as indicator of disease activity. Acta Haematol. 1997;97(4):191-5.
  143. Katrinakis G, Kyriakou D, Papadaki H, Kalokyri I, Markidou F, Eliopoulos GD. Defective natural killer cell activity in B-cell chronic lymphocytic leukaemia is associated with impaired release of natural killer cytotoxic factor(s) but not of tumour necrosis factor-alpha. Acta Haematol. 1996;96(1):16-23.
  144. Vaiopoulos G, Kyriakou D, Papadaki H, Fessas P, Eliopoulos GD. Multiple myeloma associated with autoimmune hemolytic anemia. Haematologica. 1994 May-Jun;79(3):262-4.
  145. Vaiopoulos G, Kyriakou D, Papadaki H, Kaklamanis P, Eliopoulos GD. Defective mitogen-induced cellular cytotoxicity in untreated patients with active rheumatoid arthritis. Rheumatol Int. 1994;14(3):103-7.
  146. Eliopoulos GD, Vaiopoulos G, Kyriakou D, Eliopoulos AG, Papadaki H, Katrinakis G, Alexandrakis M. Impaired release of natural killer cytotoxic factor(s) by peripheral blood lymphocytes in patients with chronic LGL-proliferative disease. Haematologica. 1993 Jul-Aug;78(4):219-24.